There's no nonstop option pairing Palm Beach's low-key private-aviation energy with Luxembourg's understated banking-capital charm, which is precisely what makes routing decisions here so interesting. Business class from West Palm Beach to Luxembourg always requires a connection, since no carrier flies this pairing directly, but that's not a drawback for seasoned travelers — it's an opportunity to select the right hub and aircraft. Delta typically routes passengers through Atlanta or JFK before a transatlantic hop, often on a Delta One-configured widebody with fully lie-flat suites and sliding doors on select aircraft, while Luxair, the Grand Duchy's flag carrier, handles the final approach into LUX with a compact, efficient business cabin ideal for short intra-European legs. Lufthansa offers perhaps the most compelling option for those willing to connect through Frankfurt or Munich, where its long-haul business class — increasingly featuring the new Allegris seat on refreshed aircraft — pairs well with excellent short-hop connectivity onward to Luxembourg's tiny, refreshingly efficient Findel Airport.
Having flown this corridor multiple times, my strong recommendation is Frankfurt as the connecting hub rather than Atlanta, simply because the FRA-to-LUX segment on Lufthansa is short, frequent, and forgiving of tight layovers, while Lufthansa's Frankfurt lounges offer a proper reset after a long transatlantic crossing. Arrive at LUX with expectations calibrated for simplicity: it's one of Europe's smallest capital airports, immigration moves quickly, and taxis into the city center take under twenty minutes, a rarity in this region. Seasonally, January through March and October into November consistently offer the softest business class fares on this pairing, as Luxembourg's business travel calendar quiets outside its EU-institution peak periods — a pattern savvy travelers exploit by booking connecting itineraries well outside summer's inflated fares.
Because pricing on this three-airline, connection-dependent route fluctuates with hub demand rather than the Luxembourg leg itself, setting up fare alerts is the smartest way to catch business class fares from West Palm Beach to Luxembourg before they disappear.