Zakynthos remains one of the Ionian's most stubbornly under-served islands for premium travelers, which is precisely why routing strategy matters so much here. There is no nonstop option, so business class from West Palm Beach to Zakynthos requires a transatlantic connection followed by a regional hop, typically through Frankfurt, Munich, or Athens depending on carrier. Lufthansa offers the most consistent long-haul product out of the East Coast, with select aircraft now featuring the new Allegris business seat — though on this routing you're more likely to encounter the established fully-flat seat on their 747-8 or A340 equipment via Frankfurt or Munich. British Airways routes through London, pairing its Club Suite (with direct aisle access on the 777 and A350 fleets) for the transatlantic leg with a short connection down to Athens before the final Aegean Airlines segment into Zakynthos.
That last leg is where insider knowledge earns its keep. Aegean operates the PBI-adjacent connection from Athens to Zakynthos on narrowbody equipment without a true business cabin in the way Americans expect, but status holders and premium ticket holders still get priority boarding and the airline's excellent Athens lounge access if the layover is long enough — worth structuring your itinerary around a three-to-four hour gap rather than a tight connection, since ZTH's small airport has limited afternoon slots and weather-related delays aren't uncommon in shoulder season. I've found that flying into Athens a day early during peak July-August season, then taking a short Aegean hop the next morning, saves enormous stress versus same-day connections when island-bound traffic peaks.
The real opportunity on this route lies in timing: April, May, September, and October consistently produce the strongest business class availability and value, both because Lufthansa and BA yield-manage their premium cabins less aggressively in shoulder season and because Zakynthos itself is far more pleasant before the July crowds arrive. Given the routing complexity and the way award and paid business space fluctuates across three carriers and multiple hubs, setting up automated fare alerts for this specific city pair is the smartest way to catch the release windows before they close.