There is no nonstop option connecting New Mexico to Catalonia, which means every itinerary in business class from Albuquerque to Barcelona routes through a domestic hub before the transatlantic hop — and after dozens of trips on this corridor, I've come to see that connection choice as the single biggest factor in trip quality. American, Delta, and United all serve this market, and each funnels ABQ passengers through a different gateway: American via Dallas-Fort Worth or Charlotte, Delta via Atlanta or JFK, and United via Denver, Chicago, or Newark. The transatlantic leg itself runs roughly 10.5 hours, and the aircraft flown on that segment matters far more than the regional jet or narrowbody used to reach it.
My strong preference is routing through JFK on Delta, where the widebody equipment to Barcelona typically features Delta One suites with sliding doors — a meaningful upgrade in privacy over older reverse-herringbone cabins still found on some United and American widebodies. If your itinerary lands you on United through Newark, look for the Polaris seat and Polaris lounge access pre-departure, which remains one of the more consistent premium arrival experiences on the East Coast. American's Flagship Suite, where assigned on the Charlotte or Dallas departures, is another strong option, particularly on aircraft with the newer Flagship Suite hard product rather than legacy business seating — so it's worth checking the specific aircraft type before booking, since American still operates a mixed fleet on European routes.
One insider tip: because ABQ has limited widebody or long-haul connectivity, booking the domestic leg with enough buffer — I recommend a minimum two-hour connection even with elite status — protects against misconnects that are more common on this route than travelers expect, given ABQ's smaller regional schedule. April, May, September, and October consistently offer the best combination of fare value and pleasant Barcelona weather, avoiding both summer crowds and premium pricing. Given how much fare and aircraft assignment can shift for this itinerary, setting up automated fare alerts is the smartest way to catch the right combination of price, hub, and seat product before it disappears.