There's something quietly satisfying about routing through Atlanta or Paris rather than the usual Northeast gateways when tackling this Southwest-to-Loire Valley itinerary, and after several bookings on this exact corridor, I can say definitively: there is no nonstop option, so business class from Albuquerque to Nantes always involves at least one connection, typically through Atlanta on Delta, or via Paris-Charles de Gaulle on Air France, with Frankfurt on Lufthansa as a third viable path. Total journey time hovers around 14-16 hours door to door once you factor in the ABQ-to-hub domestic segment, since the international long-haul leg itself runs roughly 9.5 hours eastbound.
My preference leans toward Delta's Atlanta connection when their A330-900neo or A350 is in rotation on the transatlantic leg, since Delta One's suite product with sliding privacy doors rivals anything the European carriers offer, and ABQ's Sunport makes for an easy, low-stress domestic connection with minimal security theater. Air France routes you through Charles de Gaulle, where their Business class on the 777 or A350 gets you into their La Première/Business lounge in Terminal 2E—worth the layover if you have two-plus hours, as the champagne and light dining options are genuinely restorative before the short hop down to Nantes Atlantique on an A220 or A320. Lufthansa via Frankfurt is solid too, particularly if their newer Allegris cabin has been deployed on your specific transatlantic aircraft, though that rollout has been uneven route to route, so it's worth checking your specific tail number assignment before counting on it. My insider tip: book the earliest Nantes connecting flight out of Paris or Frankfurt, since afternoon regional flights into NTE see more weather-related delays in the shoulder seasons.
January through March and October into November consistently produce the softest business class fares on this corridor, as Nantes sees lighter leisure demand outside summer festival season. Given how fares fluctuate across three separate carriers and multiple hub combinations, setting up automated fare alerts is genuinely the smartest way to catch a favorable business class fare before it disappears.