Seville remains one of Andalusia's great under-the-radar prizes, and the truth is there's no nonstop way to get there in a lie-flat seat — every itinerary for business class from Atlanta to Seville routes through a major European gateway, most sensibly Madrid, London, or Frankfurt. Iberia's connection via Madrid is the cleanest option I've flown repeatedly: the transatlantic leg rides in Iberia's A330 or A350 business cabin with proper lie-flat seats and direct aisle access on the A350, followed by a short regional hop down to SVQ. British Airways routes through London Heathrow, putting you in their Club Suite with its sliding door and forward-facing configuration on the 777 or A350, though the Heathrow-to-Seville connection adds more transit time than most travelers expect. Lufthansa's option via Frankfurt gets you into their evolving Allegris cabin on select 787 and A350 routes, though not every Atlanta departure currently features the newest product, so it's worth checking the specific aircraft before booking.
Having routed through all three hubs multiple times, my strongest recommendation is Madrid — the connection to Seville is domestic, fast, and Iberia's Terminal 4 satellite building makes for one of the more civilized transfer experiences in Europe, especially if you've got Iberia or oneworld status for lounge access. One insider tip that rarely gets mentioned: if your Iberia connection to Seville is tight, request a seat near the front of the aircraft on the transatlantic leg specifically to clear immigration faster at T4, since Seville-bound flights sometimes depart from a different satellite pier requiring a shuttle train.
April, May, September, and October consistently deliver the best combination of pleasant Andalusian weather and softer business class pricing, since summer heat and Semana Santa crowds push fares upward while thinning out shoulder-season inventory less. Given how thin premium cabin allotments are on this routing overall, setting up fare alerts through a dedicated tracking platform is genuinely the smartest move for travelers who want to catch a rare release of premium award space or a fare dip before it disappears.