There's a certain irony in Birmingham, Alabama sending its executives across the Atlantic in more comfort than most connecting itineraries deserve, but that's the reality of booking business class from Birmingham to London today. No airline flies BHM-LHR nonstop, so the operative fact worth knowing upfront is this: every business class from Birmingham to London to London itinerary routes through a major domestic hub — typically Atlanta on Delta, Charlotte or Dallas-Fort Worth on American, or Chicago/Houston on United — before the long-haul transatlantic leg. Delta's connection through Atlanta is the one I favor most, largely because it lets you settle into the Delta One suite (with its sliding privacy door on 767s and A330s) for the full crossing rather than piecing together a shorter regional business cabin. American routes you through its Flagship Business seats on 777s or 787s out of DFW or Charlotte, while United's Polaris product, especially on the 767-300ER out of Houston, remains a solid choice if your schedule favors that hub.
What separates a smooth Birmingham departure from a stressful one is timing your domestic connection with real buffer — BHM's regional jet schedules can be thin, and a missed connection on a hub like Atlanta during peak summer thunderstorm season can unravel an otherwise seamless business class itinerary. My insider tip: book the earliest viable domestic connection out of Birmingham, even if it means a longer layover, because afternoon departures from BHM are far more susceptible to weather-related cascading delays that ripple through Atlanta and Charlotte in particular. On arrival into Heathrow, Terminal 3 (where Delta and American's oneworld partners typically land) tends to move faster through immigration in the early morning than late afternoon, so redeye arrivals reward you twice over.
Deals on this corridor tend to soften in January, February, and March, and again in October and November, as both leisure and corporate demand dip between peak summer and holiday travel. Given the routing complexity and multiple carrier options, I'd strongly recommend setting up fare alerts rather than manually checking — award and revenue business class pricing on these connecting itineraries can shift quickly, and automated tracking is the only reliable way to catch the best window before it closes.