There's no nonstop path linking Logan to Otopeni, which means every business class from Boston to Bucharest itinerary involves at least one connection — a reality that actually works in the savvy traveler's favor, since it opens up three distinct routing philosophies. Delta funnels passengers through JFK or Amsterdam, pairing Delta One's suite product (complete with sliding privacy doors on 767 and A330 aircraft) with SkyTeam partner Air France-KLM metal on the transatlantic leg, then a regional hop into OTP. Turkish Airlines routes through Istanbul, and I've found this to be the most consistently comfortable option: their long-haul business class seats, generous Turkish hospitality service, and the Istanbul Lounge itself (a destination in its own right, with a simulated golf course and live cooking stations) make the layover feel like part of the trip rather than a tax on it. TAROM, Romania's flag carrier, operates the route more directly on the European end but doesn't offer a dedicated long-haul business product from Boston, so it's best used as a connector rather than your primary transatlantic carrier.
Having flown this corridor in different seasons, I'd steer clients firmly toward January through March or the October–November shoulder window — not just for softer fares, but because Istanbul and Amsterdam airports run noticeably smoother without peak summer congestion, which matters enormously when your connection window is tight. My insider tip: if routing through Istanbul, request a fast-track transfer at IST during booking or via Turkish's business class desk — the airport's sheer size means even generous layovers can evaporate without it. Arrival into Otopeni is refreshingly low-stress regardless of carrier, with a compact terminal that rarely produces the immigration bottlenecks common at larger European hubs.
Because pricing on this Boston–Bucharest corridor swings significantly with fuel surcharges and seasonal demand from the Romanian diaspora, setting up automated fare alerts is genuinely the smartest way to catch the periodic dips before they vanish.