Hannover rarely gets the glossy nonstop treatment reserved for Frankfurt or Munich, which is precisely why the routing puzzle matters more here than almost anywhere else in Germany. There is no direct service between Boston and Hannover, so business class from Boston to Hannover means connecting through a major European or transatlantic hub, and after dozens of trips on this corridor, I can say the smartest play is Lufthansa via Frankfurt, with Delta via Amsterdam or Paris (using partner KLM/Air France metal) and American via London or Frankfurt as viable alternates. Lufthansa's advantage is the short intra-German hop afterward, often on an A320 with recliner-style business seating, connecting seamlessly to the transatlantic leg where you may find their newer Allegris business suites with sliding doors, though the older 1-2-1 configuration on 747-8s and A340s still flies plenty of Frankfurt rotations.
Frankfurt Airport remains the linchpin, and my insider tip is to build in at least 90 minutes for the connection even with a Lufthansa-to-Lufthansa itinerary, since immigration lines for non-Schengen arrivals can eat your buffer fast — and if you clear passport control in Frankfurt rather than waiting until Hannover, you'll skip a second immigration check entirely. Delta's Amsterdam routing via KLM's A330 World Business Class is a comfortable alternative if Lufthansa award space is tight, and American's London Heathrow connection onto British Airways gives you a shot at Club Suite for the transatlantic sector, though the Heathrow-to-Hannover leg drops you into a much smaller regional cabin.
Seasonality on this route mirrors broader transatlantic patterns rather than anything unique to Hannover itself: January, February, March, October, and November consistently offer the softest business class demand, since Hannover's trade fair calendar (notably CeBIT's successor events and Hannover Messe in spring) pushes fares up sharply in April. Given how thin premium inventory can be into a secondary German city, I'd strongly recommend setting up automated fare alerts rather than manually checking, so you catch the inevitable pricing dips the moment they surface.