Charleston's compact terminal makes for an easy start to what is, inevitably, a two-stop puzzle: there is no nonstop business class from Charleston to Istanbul, so the real decision is which connection you build your itinerary around. Delta routes most naturally through JFK or Atlanta before handing you to a transatlantic partner, while United funnels through Newark or Washington Dulles onto Star Alliance metal.
Turkish Airlines has built a genuine reputation among frequent flyers for its business class catering, and the mid-flight "flying chef" presentation, on aircraft where it's offered, to be one of the more memorable meal services across the Atlantic — worth requesting your preferred protein early rather than waiting for the cart. If you connect through JFK, budget real time: Turkish operates from Terminal 1, and a same-terminal or short walk connection is far easier than the alternative of crossing from a domestic terminal on a tight layover. Istanbul Airport itself rewards early arrival too, since its business lounge is enormous and worth wandering rather than rushing through security at the last minute.
Award space and fares both loosen up considerably in the shoulder and winter months — January, February, March, October, and November are consistently the softest windows on this corridor, as Turkish leisure demand dips outside summer and Ramadan/holiday peaks. Because pricing on this three-airline, multi-connection route can swing significantly week to week, setting up automated fare alerts is the smartest way to catch a business class fare worth booking before it disappears.