Nuremberg rarely shows up on the radar of American business travelers, which is exactly why the smart ones have already figured out how to get there in comfort. There is no nonstop option for business class from Charlotte to Nuremberg, so the routing decision becomes the whole game: American Airlines and United both funnel through their transatlantic gateways—American via Philadelphia or Charlotte-to-Munich style connections via partner metal, United via Newark or Washington Dulles—while Lufthansa, the more natural choice given Nuremberg's proximity to Frankfurt and Munich, lets you connect onto its own European network with minimal friction. Lufthansa's Frankfurt or Munich hub connection is generally the most efficient path, often landing you on an A350 or 747-8 with Lufthansa's business class seating for the transatlantic leg before a short regional hop into Nuremberg.
Having flown this corridor more times than I can count, I've learned that Munich is the superior connection point over Frankfurt if your itinerary allows a choice—immigration and security recheck move faster, and the walk to regional gates is shorter, which matters when you're nursing jet lag after a long-haul flight. Lufthansa has been rolling out its new Allegris business class cabin on select long-haul aircraft, featuring suites with doors on some configurations, though older 747-8 and A340 business seating with direct aisle access on most units is still common on this corridor, so it's worth checking your specific aircraft type at booking. One insider tip: Nuremberg's airport is compact enough that even a tight 60-minute connection from Munich is comfortable, so don't over-buffer your itinerary and waste hours in a transit lounge.
Seasonally, January through March and October into November consistently produce the best business class fares on this Germany-bound routing, as Bavarian trade fairs and Christmas market season create demand spikes just outside those windows that push prices upward. Given the volatility of transatlantic business fares and the limited nonstop competition on this city pair, setting up automated fare alerts is genuinely the smartest move you can make before committing to a booking date.