There's something delightfully anachronistic about connecting through the Azores archipelago in a lie-flat seat, and it's a route I've come to appreciate for its off-the-radar efficiency. Nonstop business class from Charlotte to Ponta Delgada doesn't exist today, so the real question is which one-stop routing rewards you best. American Airlines, via its partnership with TAP Air Portugal, is the most sensible connection I've flown, typically routing through Philadelphia or JFK before continuing to Lisbon and onward to PDL, or via TAP's own Lisbon hub direct to the islands. Delta offers an alternative through JFK or Boston with partner metal into Lisbon, then a short TAP hop to São Miguel. TAP's A321neo and A330 business class cabins, with their flat-bed seats on long-haul segments, are the product to seek out when the connection allows it — Delta's own A330 or A350 Delta One suites are the stronger domestic-to-transatlantic leg if your itinerary routes that way.
The insider move here is to fly the transatlantic leg in a true flat-bed product (TAP's A330 or Delta One) and treat the Lisbon-to-Ponta Delgada segment as a short, almost incidental regional hop — don't expect lie-flat seating on that final leg, and don't overpay for it. Arriving into Lisbon with at least a two-hour buffer is wise, since TAP's connections to the Azores depart from a different pier than most transatlantic arrivals, and immigration lines at LIS can be unpredictable in high season. I've found shoulder-season travel — January through March, and again in October and November — yields not just better fares but a noticeably calmer Ponta Delgada airport, which is a single-runway, low-traffic field that rewards travelers who avoid the July-August surge of European vacationers.
Because pricing on this route fluctuates with TAP's promotional cycles and Delta's transatlantic sales far more than with steady demand, setting up automated fare alerts for Charlotte to Ponta Delgada business class is the smartest way to catch a favorable window before it closes.