Poznan remains one of Europe's most delightfully under-the-radar business destinations, and after routing through this corner of Poland a dozen times over the years, I can tell you that securing business class from Charlotte to Poznan requires a bit of strategy since no carrier flies the sector nonstop. The practical reality: every itinerary connects through a major European hub, with Lufthansa via Frankfurt or Munich, United via its transatlantic partnership through Newark and Frankfurt, and LOT Polish Airlines via Warsaw or Chicago as the three viable routings — and that Frankfurt-Poznan or Warsaw-Poznan final leg is almost always a modest regional jet, so don't expect lie-flat seating on the last hop. This is a genuinely useful fact for anyone Googling the route: the long-haul comfort happens on the transatlantic segment, not the short intra-European connector.
My preference has long been routing via Frankfurt on Lufthansa, where their long-haul 747-8 or A340 business class cabins offer generous width and Lufthansa's signature service polish, though if you're lucky enough to land one of the newer Allegris-configured aircraft on the transatlantic leg, the redesigned suites with sliding doors are a meaningful step up. United's Polaris seats, found on their 767s and 777s out of Newark, are another solid option if you're connecting from Charlotte domestically first — just build in a comfortable buffer at Newark, as European departures cluster in the early evening and security lines can bottleneck. LOT's connection through Warsaw Chopin is worth considering too, particularly since it keeps you on Star Alliance metal the entire way and their Warsaw hub has become noticeably more efficient in recent years for tight connections onward to Poznan.
Seasonality matters enormously here: January, February, March, October, and November consistently offer the softest fares, since Poznan's trade fair calendar (Poznań International Fair) drives business demand in spring and early autumn, pushing premium cabin pricing up outside those windows. My insider tip — book the Frankfurt-Poznan connector as a separate LOT or Lufthansa Regional ticket only if your main itinerary allows a long enough layover, since misconnects on this final leg aren't well protected by some fare classes. Given how much these premium fares fluctuate by hub and season, setting up dedicated fare alerts for this specific Charlotte-Poznan corridor will save you from watching a great deal slip by.