Denver's altitude and Edinburgh's cobblestone charm make for an odd but rewarding pairing, and the truth about this route is straightforward: there is no nonstop service, so business class from Denver to Edinburgh always routes through a connecting hub, typically London Heathrow, Newark, or occasionally Chicago, depending on which of the three carriers—United, British Airways, or Virgin Atlantic—you choose. United flies its Polaris product on the transatlantic long-haul legs out of Newark or Chicago, with lie-flat seats and its dedicated Polaris lounges making the connection painless if you build in enough time. British Airways routes travelers through Heathrow, where its Club Suite—complete with a closing door and direct aisle access on the 787 and A350 fleets—has become one of the more consistent hard products in the sky, though I'd steer connecting passengers toward Terminal 5's shorter transfer times rather than risk a T3-to-T5 shuffle on arrival from the US.
Virgin Atlantic, flying through Heathrow as well, brings its Upper Class Suite on select A350 and 787 aircraft, complete with the Loft social space on some configurations—a nice touch if you're breaking up the journey with a few hours before the short Edinburgh hop. My insider tip after years of booking this connection: the final Heathrow-to-Edinburgh or Newark-to-Edinburgh segment is often operated with a domestic-style narrowbody cabin, so don't expect the same seat you had on the transatlantic leg—treat it as a short regional hop and save your enthusiasm for the long-haul segment where the real product shines.
Seasonality matters more than most travelers assume here. January, February, March, October, and November tend to yield the most favorable business class availability and pricing, largely because Edinburgh's summer festival season and Highland games draw heavy leisure demand that pushes premium cabins toward capacity. Given the route's dependence on connections and the fluctuating award space across United, British Airways, and Virgin Atlantic, setting up fare and award alerts is genuinely the smartest way to catch the best openings before they disappear.