Valencia rarely gets the nonstop treatment from American gateways, and that's precisely what makes routing strategy the whole game here. There is no direct service between Detroit and Valencia, so business class from Detroit to Valencia inevitably means a connection through Madrid, London, or Frankfurt — and which hub you choose shapes the entire experience more than the transatlantic leg itself. Iberia's Madrid connection is the most elegant option for this itinerary, since Iberia operates widebody business class on the DTW-MAD sector (often in partnership with Delta's transatlantic footprint) and then hands you off to a short intra-European hop into VLC, sometimes on a regional jet with recliner seating rather than lie-flat — worth knowing so expectations are calibrated. British Airways via London and Lufthansa via Frankfurt are the alternatives, each with their own connection-time trade-offs at Heathrow Terminal 5 or Frankfurt's sprawling Terminal 1.
Having flown all three routings repeatedly, I'd steer discerning travelers toward Iberia's A330 or A350 business class product on the Madrid leg — the A350 cabin, when you can secure it, offers proper lie-flat direct-aisle-access seating and noticeably quieter cabin acoustics than the older A330s still working some rotations. Lufthansa's Frankfurt connection is worth considering if your dates align with their newer Allegris cabins, which are gradually rolling out on select long-haul aircraft, though availability on this specific corridor remains inconsistent, so confirm equipment before booking. British Airways' Club Suite, with its sliding door and forward-facing layout, is a strong fallback, particularly if Heathrow's shorter MAD-style connection windows appeal to you.
One insider tip: build in at least a 2-hour buffer in Madrid regardless of carrier, since Iberia's domestic-to-international connection process at Barajas can involve a terminal shuffle that catches even seasoned flyers off guard. Shoulder season — April, May, September, and October — consistently delivers the strongest business class availability and value on this corridor, as Valencia's tourism surges push summer fares upward while autumn light and Fallas-season spring keep things civilized. Given how much these fares fluctuate by hub and carrier, setting up dedicated fare alerts for this specific city pair is the smartest move before committing to dates.