Southwest Florida's palm-lined runways and the medieval spires of Bucharest's Old Town rarely appear in the same sentence, but this improbable pairing has become one of my favorite routings to plan for clients seeking value on an underserved corridor. There is no nonstop option: business class from Fort Myers to Bucharest requires a connection, and the most reliable itineraries route through Atlanta or JFK on Delta before transferring to a European partner, or via Istanbul on Turkish Airlines, or through a Western European gateway to catch TAROM's own metal into OTP. Total journey time typically lands around 11.5 hours of actual flying once you account for the transatlantic leg and the connection, and travelers should know that Delta's long-haul segment is the one to prioritize for lie-flat comfort, since domestic connectors out of RSW are usually regional jets or narrowbodies with recliner seating only.
My preferred build for this trip uses Delta One on the transatlantic sector — either the Suites product on select 767/777 aircraft or the older but still comfortable Delta One seat on A330s — connecting through JFK or Atlanta, then onward via a joint-venture partner into Bucharest. Turkish Airlines is the wildcard worth considering: their Istanbul hub is a phenomenal midpoint, and their business class cabin, with proper Turkish hospitality and strong catering, makes the OTP connection feel like a reward rather than a chore. If you find yourself routing through Istanbul, budget extra time to enjoy the lounge before the short hop to Bucharest — it's one of the more indulgent connection experiences in this part of the world. TAROM itself operates narrowbody aircraft on regional European routes, so don't expect flatbed seating on that final leg regardless of cabin booked.
January through March and again in October and November are consistently the softest months for premium fares here, largely because Romanian leisure demand dries up outside summer and shoulder-season city breaks. A tip few advisors mention: booking the Delta-TAROM combination through a single ticket, rather than separate reservations, protects you if the connection in Bucharest or a European gateway gets tight. Given how erratically award space and fares move on this three-carrier route, setting up automated fare alerts is the smartest way to catch a genuine deal before it disappears.