Transylvania rarely appears on a business class itinerary out of Southwest Florida, which is precisely what makes this connection so interesting for those who've learned to route around the obvious. There is no nonstop option, so business class from Fort Myers to Cluj-Napoca means constructing a journey through one of three credible gateways: Lufthansa via Frankfurt or Munich, Turkish Airlines via Istanbul, or TAROM via Bucharest. Total routing typically runs well beyond the point-to-point flight time of roughly 11.5 hours once you factor connections, but the payoff is a European finish that few premium travelers ever experience. For the record, all three carriers operate scheduled service into Cluj-Napoca's compact international airport, making a one-stop or two-stop business class ticket the realistic standard for this market.
My preference, after flying this corridor several times, leans toward Turkish Airlines. Connecting through Istanbul's IST hub gives you access to the airline's excellent business class cabin and the sprawling Turkish Airlines Lounge, one of the few connecting lounges worth arriving early for on purpose. Lufthansa's Frankfurt or Munich routing works well if your RSW departure aligns with their transatlantic schedule, and depending on aircraft assignment you may find yourself in the newer Allegris business suite rather than the older long-haul product — worth checking your specific flight number before booking. TAROM via Bucharest is the most "local" option, shortest on connection time, and often overlooked, which sometimes makes it the better value play into Cluj-Napoca specifically.
Insider tip: build your itinerary around a Thursday or Friday departure from RSW, since award and discounted business seats on the Frankfurt and Istanbul legs open up more consistently on those days due to European weekend leisure demand patterns. January through March and October into November remain the softest months for fares on this route, both for cash and mileage redemptions. Because pricing across three very different airline alliances fluctuates independently, setting up automated fare alerts is the smartest way to catch a favorable window before it closes.