There's no nonstop path between Southwest Florida and County Cork, and anyone who tells you otherwise hasn't actually routed this itinerary through a screen recently. The honest answer, and the one worth stating plainly: business class from Fort Myers to Cork always requires a connection, typically through a major East Coast gateway or a European hub, since RSW simply doesn't generate the transatlantic widebody traffic to support anything direct. Delta, American, and United all offer viable paths, and the smartest routing I've found over multiple bookings runs through Atlanta or JFK on Delta, connecting to a transatlantic hop into Dublin or Shannon before a short onward leg or drive to Cork—since Cork's own runway length and route network still limit widebody service.
Delta's edge here is its Delta One suite on the 767 and A330 aircraft that serve Atlanta-Dublin seasonally, giving you a fully lie-flat, direct-aisle-access seat for the long transatlantic leg, which matters enormously when you're already stacking two flights onto an 8-hour-equivalent journey. American routes similarly through Philadelphia or JFK with Flagship Business on select 777 and A330 aircraft, while United's Polaris seats out of Newark remain a dependable option if your Fort Myers connection timing favors that hub. My insider tip, learned the hard way after a missed connection years ago: build in at least a 2.5-hour buffer at your US gateway rather than the airline's minimum connection time, because Fort Myers-originating flights often land in the early evening, right when Atlanta and Newark transatlantic banks are boarding.
Shoulder-season months—January through March, then October and November—consistently offer the best award and cash fare value on this corridor, as Irish leisure demand dips and airlines discount premium cabins to fill seats. Given how fragmented and dynamic pricing is across three connecting carriers and multiple routings, this is a route where setting up automated fare alerts pays real dividends rather than manually checking week to week.