There's no nonstop route between Bradley International and Nantes Atlantique, so the real craft of booking business class from Hartford to Nantes lies in choosing the right connection rather than chasing a mythical direct flight. In practice, that means routing through Paris, Amsterdam, or a German gateway, with Delta and Air France offering the most natural pairing via a transatlantic hop into Paris-Charles de Gaulle followed by a short regional connection on Air France's Airbus A220 or A320 fleet down to Nantes. Lufthansa's alternative through Frankfurt or Munich works well for travelers who prefer German efficiency and want to sample Lufthansa's long-haul business class, typically a Boeing 777 or A340 lie-flat seat, before switching to a narrowbody for the final leg into western France.
Having flown this corridor repeatedly over the years, I've found the Delta-Air France codeshare from JFK or Boston to be the smoothest combination for New Englanders, since it often allows a single connection through Paris rather than two. Delta's A330 or A350 business class, with its Delta One suite on select aircraft, pairs nicely with Air France's Business class product on the transatlantic leg if you're ticketed through their joint venture. My insider tip: build in at least a two-hour connection window at CDG's Terminal 2E, since immigration and the walk to the domestic Nantes gates can eat time quickly, especially during the summer surge when Nantes sees heavy leisure traffic from returning French expatriates.
Seasonality matters enormously here — January, February, March, October, and November consistently yield the most favorable business class availability and pricing, as demand dips outside the Brittany coast's summer high season. Because award space and fares on this Hartford-to-Nantes business class journey shift quickly with the transatlantic joint venture's pricing algorithms, I'd strongly recommend setting up automated fare tracking so you catch these seasonal windows the moment they open rather than relying on manual searches.