Bradley International isn't a hub anyone associates with long-haul luxury, which is precisely why the routing puzzle to Zagreb rewards careful planning. There is no nonstop option, so business class from Hartford to Zagreb inevitably runs through a major European or transatlantic gateway, with Frankfurt via Lufthansa or a Delta/JFK-Amsterdam-style connection into Croatia Airlines' regional network being the two dominant strategies. Total journey time typically lands around 12-14 hours once you factor in the connection, though the transatlantic leg itself clocks in near 9.5 hours from the East Coast. My preferred build is Delta out of JFK or Boston in Delta One, transferring onto a Lufthansa or Croatia Airlines short-hop into Zagreb, since Delta's widebody lie-flat product on the transatlantic sector is where you want your rest to happen — the Zagreb feeder legs are short enough that seat type matters far less.
Lufthansa routings through Frankfurt deserve a specific mention if you can secure their Allegris cabin on the applicable aircraft, as it's a meaningfully upgraded experience over the older long-haul business seats still flying much of the Frankfurt fleet — worth checking your specific tail number at booking rather than assuming consistency. Croatia Airlines (OU) operates the final short intra-European hop and doesn't offer a premium cabin worth chasing, so treat that segment purely as a connector, not a product to plan around. My insider tip: build in a 3+ hour connection in Frankfurt if flying Lufthansa, since Star Alliance business class arrivals there often land in remote terminal areas requiring bus transfers to the Schengen connection zone — tight connections here cause more missed flights than travelers expect.
January through March and again October into November are consistently the softest months for fares on this corridor, as Croatia's tourist season collapses well before ski season builds elsewhere in Europe. Zagreb simply doesn't carry the summer premium that Dubrovnik or Split does, which makes shoulder-season business class fares here unusually reasonable relative to other Central European capitals. Given the routing complexity and the way award and revenue fares fluctuate week to week on connections through Frankfurt or JFK, setting up automated fare alerts for this specific city pair is the smartest way to catch a business class fare drop before it disappears.