There's a certain irony to island time colliding with Andalusian time, and after routing this journey more times than I can count, I've settled into an appreciation for how deliberately you must plan business class from Honolulu to Seville, since no carrier offers anything close to a one-stop solution across two oceans and a continent. The practical reality: there's no nonstop option, and the most reliable itinerary threads through the mainland US before connecting onward through a major European gateway, typically London Heathrow via British Airways or Madrid via Iberia. American Airlines handles the transpacific-to-transcontinental leg well from Honolulu, positioning you for a same-alliance handoff onto BA's Club Suite or Iberia's A350 business class, both of which feature direct-aisle access and proper doors—a meaningful upgrade over older herringbone products still flying some legacy Iberia widebodies.
My preferred routing funnels through Los Angeles or Dallas on American, then transfers to either British Airways at Heathrow's Terminal 5 or Iberia at Madrid's Terminal 4S for the short hop down to Seville, since SVQ itself has no long-haul widebody service and never will given its modest runway and regional focus. The insider move here is booking the Iberia connection through Madrid rather than the London routing whenever schedules allow: T4S is a dramatically calmer transfer experience than Heathrow's T5, especially after a long transpacific-transatlantic combination, and Iberia's domestic Spanish network treats Seville almost like a shuttle hop, with multiple daily frequencies that give you real flexibility if your inbound leg runs late. Aim for a minimum three-hour buffer in either hub given the sheer distance covered.
Seasonally, April, May, September, and October reward patient travelers, both for pleasant Andalusian weather away from summer's brutal heat and for softer premium cabin demand across the Pacific and Atlantic segments alike. Because pricing on this multi-carrier, multi-alliance routing fluctuates with each individual segment's demand curve, setting up automated fare alerts across American, British Airways, and Iberia is the smartest way to catch the rare moments when all three segments align favorably.