There is no nonstop route linking these two cities, so the real question for anyone booking business class from Honolulu to Stuttgart isn't which airline flies direct—none do—but which connection minimizes the pain of a journey that spans roughly 18-20 hours of total travel with a stopover. American, Delta, and United all serve this corridor via their respective mainland hubs, typically routing through Los Angeles, San Francisco, Dallas, Chicago, or New York before crossing the Atlantic to Frankfurt or Munich, with a final short hop or rail connection into Stuttgart. American's transatlantic leg often features their Flagship Suite on 777-300ERs out of hubs like Dallas or Philadelphia, while Delta's A330-900 and A350 aircraft offer Delta One suites with full-suite doors on the long Pacific segment from Honolulu. United, meanwhile, leans on its Polaris business class seats, particularly strong on the San Francisco-to-Frankfurt stretch.
Having routed this journey multiple times, my strong preference is booking the Honolulu-to-mainland segment on the carrier's widebody rather than a regional jet, since a lie-flat seat across the Pacific matters just as much as the transatlantic leg when you're covering this much ground. A frequently overlooked insider tip: if your itinerary connects through Frankfurt, opt for a layover of at least 90 minutes and take the direct Lufthansa-operated rail link (the "Lufthansa Express Rail") to Stuttgart's main station rather than booking a connecting flight—it's often faster, more reliable in winter weather, and skips a second security screening entirely. Munich connections tend to run smoother in summer months when weather delays are less frequent.
January through March and October through November consistently offer the best value on this Pacific-to-Europe combination, as demand dips between peak ski season and summer travel. Because pricing on multi-carrier itineraries like this fluctuates constantly based on award availability and seasonal demand shifts, setting up fare alerts is the smartest way to catch a premium cabin deal before it disappears.