Innsbruck's alpine runway, hemmed by mountains that make for one of Europe's more dramatic approaches, isn't a market anyone serves nonstop from the Midwest — and that reality shapes everything about booking business class from Indianapolis to Innsbruck. There is no single-carrier nonstop; instead, the smart routing runs through Delta or United via their major transatlantic gateways, or through Austrian Airlines via Vienna, with a final short hop or rail connection into Tyrol since Innsbruck's own jet service is limited seasonally to winter ski traffic and summer leisure demand. My preferred build is Indianapolis to Detroit or Atlanta on Delta, then a transatlantic leg in Delta One suites with sliding doors and lie-flat seating, connecting in Amsterdam or Paris before a partner or Austrian regional flight completes the journey. United routes similarly well through Chicago or Newark in Polaris business class, with its dedicated Polaris lounges at both hubs easing the layover considerably.
Having flown this corridor more times than I can count chasing ski season, I've learned that Vienna is actually the more reliable connection point than trying to force a Frankfurt or Munich routing, because Austrian Airlines' own metal into Innsbruck (when operating) or its close rail partnership via ÖBB from Vienna's airport makes for a seamless final leg, and Austrian's business class on European stretches includes proper hot meals rather than the snack service you'll find on some competitors. The insider move: book into Munich instead when Innsbruck slots are tight in peak ski weeks, then take the two-hour train through the Bavarian Alps into Tyrol — it's often faster door-to-door than waiting for a connecting flight, and the scenery alone justifies it.
January through March and again in October and November consistently produce the softest business class fares on this corridor, as airlines discount the shoulder periods between ski season peaks and summer hiking crowds. Given the multi-airline routing complexity here, setting up fare alerts across Delta, United, and Austrian is the most reliable way to catch the inevitable pricing dips before they disappear.