Split's Dalmatian coastline rewards patience, and after a decade of routing through Europe's hub cities to reach it, I can say with confidence that there's no nonstop option worth waiting for from Indiana's capital. Business class from Indianapolis to Split requires a connection, and the smartest routings run through Delta's Atlanta or Detroit hubs into a European gateway like Amsterdam or Paris, or via United through Newark and onward through Frankfurt or Munich. American routes through Philadelphia or Charlotte with a European partner connection, typically landing at Heathrow or Zurich before the short hop down to Split's compact SPU airport. Total journey time hovers around 10 hours of actual flying, but factor in three to four hours of connection buffer given how seasonal and thin the Croatia flights can be, especially outside peak summer.
Delta's transatlantic metal typically features their Delta One suites with all-aisle access and sliding doors on 767 and A330 aircraft, a genuine upgrade over older configurations still flying some Atlanta routes. United's Polaris seats, now widely rolled out across their 767 and 777 fleet, offer similar direct-aisle access and Saks Fifth Avenue bedding that makes the long haul segment bearable before the shorter connecting flight into Croatia. American's business class varies more by aircraft, so if flexibility allows, seek out their Flagship Suite on 777-300ER equipped routes rather than the older 767 business seats, which lack the same privacy and lie-flat comfort. My insider tip: book the connecting European-to-Split segment as early morning as possible, since Croatia Airlines and partner regional carriers often reduce frequency or cancel afternoon rotations during shoulder season, and Split's airport gets delightfully manageable before the cruise-ship crowds descend midday.
April, May, September, and October remain the sweet spot for this itinerary, both for Dalmatian weather and business class award availability, since summer capacity gets absorbed by leisure travelers chasing the Adriatic sun. Given how thin premium cabin inventory runs on the Croatia-adjacent legs, setting up fare alerts for this specific Indianapolis-Split corridor will save you from constantly refreshing search engines yourself.