There's a certain irony in booking a flight to the birthplace of Western philosophy from a city built entirely on illusion, but that contrast is part of what makes this itinerary so satisfying to plan well. No airline currently flies nonstop between the two cities, so business class from Las Vegas to Athens always routes through a domestic or transatlantic hub, and the connection you choose matters more than people realize. Delta typically routes travelers through JFK or Atlanta before crossing on its Delta One suites, with the reverse-herringbone seating on the A330 or A350 offering full aisle access and reliable direct-aisle privacy on the transatlantic leg. American tends to funnel LAS-ATH connections through Philadelphia or JFK, putting you on its 777 or 787 with Flagship Suite seating, complete with sliding doors on select aircraft. United, meanwhile, often routes through its Newark or Chicago hubs, placing passengers in Polaris seating on the 777-300ER or 787-9, both of which include the brand's signature Saks Fifth Avenue-designed bedding.
Having flown this corridor multiple times, my advice is to build in at least a 90-minute buffer at whichever East Coast hub you choose, since winter storms and summer thunderstorm patterns along the Eastern Seaboard can cascade into missed connections that ripple all the way to Athens. A quieter insider move: flying into Athens midweek, particularly Tuesday or Wednesday, tends to land you in a noticeably calmer arrivals hall at ATH, which makes the crawl through passport control far more civilized after a long overnight crossing. Seasonally, April, May, September, and October reward patient shoppers, since airlines price this corridor aggressively to fill premium cabins before and after the punishing summer heat both in Las Vegas and the Greek islands.
Given the multiple carriers and routings involved, fares on this itinerary fluctuate more than travelers expect, often shifting week to week depending on hub congestion and seasonal demand. Setting up fare alerts for this specific city pair is the smartest way to catch the inevitable pricing dips before they disappear.