There's no nonstop escape from the Nevada desert to Northern Ireland, which is precisely what makes routing strategy the whole game here. There is no direct service connecting these two cities, so business class from Las Vegas to Belfast always involves a connection, typically through Atlanta, New York-JFK, or Chicago before crossing the Atlantic. Delta remains my preferred carrier for this itinerary, pairing a domestic red-eye or morning departure from LAS with a widebody Delta One product on the transatlantic leg out of JFK or Atlanta — expect the reverse-herringbone seating and Westin Heavenly bedding that Delta has rolled out across its 767 and A330 fleets. American Airlines offers a similar structure via Philadelphia or Charlotte, with Flagship Business seating on select transatlantic aircraft, while United funnels passengers through Newark or Chicago-O'Hare using its Polaris seat, which remains one of the more private herringbone designs in the sky.
Having flown this connection combination more times than I can count, my strongest advice is to build in at least a two-hour buffer in your U.S. gateway city, since LAS departures can run late during winter storm season and you do not want to miss a tightly-booked business class seat across the pond. Atlanta is the most reliable hub for weather consistency and Delta's Sky Club access softens a long layover considerably; if you're routing through JFK instead, request Terminal 4's dedicated Delta One check-in lane, a lesser-known perk that shaves real time off the security crawl. Once in Belfast, arrival at George Best Belfast City Airport is refreshingly quick regardless of carrier, since all three airlines route you through London or a European connection point before the final short hop.
January through March and October into November consistently produce the softest fares on this corridor, as Belfast sees limited leisure demand outside summer festival season, making shoulder months ideal for stretching out in a lie-flat seat without a peak-season premium. Given how sensitive fares are to routing and connection city, this is a route where setting up automated fare alerts pays dividends — letting the deals come to you rather than chasing them manually.