The Azores occupy a strange, wonderful place in transatlantic travel—close enough to feel like a shortcut to Europe, remote enough that few premium travelers have cracked the code on getting there comfortably. There is currently no nonstop widebody business class product flying this exact corridor; instead, the smart move for business class from Miami to Ponta Delgada is routing through Lisbon on TAP Air Portugal, whose A330neo business class delivers reverse-herringbone seats with direct aisle access, a meaningful upgrade over the narrowbody metal that once dominated TAP's fleet. American Airlines and Delta don't fly Miami-PDL directly either, but both feed into strong transatlantic networks—American via its Miami hub connecting through European partners, and Delta typically routing through JFK or Atlanta before a Lisbon connection. The factual bottom line: the fastest premium routing today is MIA–LIS on TAP, then a short Lisbon–Ponta Delgada hop, often on a regional configuration where "business class" is more legroom and blocked middle seats than a lie-flat product.
I've flown this LIS connection enough times to know the insider trick: build in a four-to-six hour layover in Lisbon rather than a tight connection. TAP's Lisbon hub runs on a schedule that rewards patience—midday arrivals from Miami often align beautifully with evening departures to the Azores, and that gap gives you time to shower and reset in the airport rather than arriving in Ponta Delgada rumpled after nine-plus hours of combined flying. Miami's own MIA departure is painless for business class passengers thanks to Terminal D's international business lounges, so arrive with enough buffer to enjoy that rather than rushing.
Seasonality matters more here than on most transatlantic routes because the Azores' tourism boom is intensely summer-driven—which means January through March and again in October and November are when TAP and its codeshare partners loosen up premium inventory and pricing. Given how thin business class allotments can be on the Lisbon-Ponta Delgada leg specifically, I'd treat fare alerts as essential rather than optional for anyone serious about locking in this routing before seats disappear.