Seville remains one of Andalusia's most rewarding surprises precisely because it demands more effort to reach than Madrid or Barcelona, and that's what makes routing decisions here so interesting. There's no nonstop option: business class from Miami to Seville always requires a connection, typically through Madrid or London, since neither American, Iberia, nor British Airways currently operates direct MIA-SVQ service. My preferred routing is American Airlines' Miami-Madrid nonstop, which frequently runs on the 787-9 with Flagship Business, followed by a short Iberia hop into Seville—Iberia operates that domestic Spanish network extensively and treats the connection almost like a regional shuttle. Alternatively, British Airways loyalists can fly MIA-London on the 777 or 787 in Club Suite, that fully enclosed suite with sliding door BA rolled out fleet-wide, then connect via Heathrow to Madrid or Seville on a partner or codeshare.
The Madrid connection is the one seasoned travelers should study closely, because Iberia's home hub at Terminal 4 is refreshingly efficient for tight layovers—Star Alliance-style long walks aren't an issue here, and Iberia's own lounge network makes a two-hour connection genuinely comfortable rather than stressful. My insider tip: book the Iberia domestic leg as a separate paid ticket if the connection window is short, since same-day protection on partner itineraries between American and Iberia isn't always guaranteed, and a missed short-haul hop to Seville can otherwise strand you overnight in Madrid.
Shoulder season—April, May, September, and October—is when this routing rewards patience, both climatically (Seville in July is brutal, often exceeding 100°F) and financially, as premium cabin award space and fare sales on the transatlantic legs loosen up considerably. Because pricing on this three-airline corridor fluctuates with Iberia and American's joint venture fare filings, setting up automated fare alerts is the smartest way to catch a business class fare drop before it disappears.