Nuremberg's small, charming airport has no direct widebody service from the American Midwest, which means anyone booking business class from Minneapolis to Nuremberg is really booking a connection strategy—and after years of routing through Europe on this itinerary, I can say the choice of hub matters as much as the airline. Delta's nonstop MSP–Amsterdam service on a Delta One-equipped A330 or 767, paired with a KLM Cityhopper or Lufthansa regional jet down to Nuremberg, is the most reliable combination, but Lufthansa's own MSP–Frankfurt run followed by a short hop to NUE gives you access to Frankfurt's efficient Terminal 1 transfer process, which is far less chaotic than Amsterdam during peak summer months. United routes through Chicago or Newark to Frankfurt or Munich, and while their 767 and 787 Polaris cabins are comfortable, the extra domestic leg from MSP eats into your total journey time, which already runs close to ten hours on the transatlantic segment alone.
If Lufthansa is your carrier, try to book the Frankfurt–Nuremberg feeder on their new Allegris-configured aircraft when schedules allow; the airline has been gradually rolling out Allegris business suites on select European mainline routes, and even a short intra-German hop in a modern cabin beats the older regional jet configurations still flying much of this network. My insider tip: fly into Munich rather than Frankfurt when connecting on Lufthansa, since Munich's rail and shuttle connections to Nuremberg (under two hours by train) are often faster and less stressful than a same-day short-haul flight, especially during winter weather delays that plague Frankfurt's tarmac in January and February.
Deal season on this corridor tends to cluster in January through March and again in October and November, when business travel to Germany's industrial trade fair circuit—Nuremberg hosts major toy and electronics expos—creates unpredictable fare swings rather than steady premiums. Because pricing on this MSP–NUE corridor fluctuates with connection routing as much as seasonality, setting up fare alerts is the smartest way to catch a genuine business class opportunity before it disappears.