Nuremberg's modest regional airport has never hosted a nonstop widebody from the Gulf Coast, so anyone booking business class from New Orleans to Nuremberg is really booking a two-flight itinerary anchored by a strong transatlantic segment and a short European hop. The most reliable routing runs through Atlanta or Amsterdam on Delta, whose joint venture with KLM and Air France gives you access to A330 or A350 business class across the pond before a regional connector completes the trip into Nuremberg or nearby Munich, which I often recommend as an alternative arrival point given its far more robust Lufthansa network. American routes you through Charlotte or Philadelphia into Frankfurt or Munich on its own metal, tapping into oneworld partner Finnair or British Airways for the long-haul leg, while United funnels through Newark or Houston into Frankfurt, putting you on its Polaris business class seat with direct aisle access on the 767 or 777 fleet.
Having flown this connection repeatedly over the years, I've learned that Munich is the smarter gateway of the two German options — its immigration lines move faster than Frankfurt's notoriously congested Terminal 1, and the drive or train onward to Nuremberg takes under two hours, often faster than waiting for a tight regional connection. If your itinerary allows, request the layover in Munich rather than Frankfurt; Lufthansa's home hub lounges are simply a more comfortable place to decompress after eight-plus hours in the air, even when you're technically flying a Star Alliance partner rather than Lufthansa itself. Business travelers heading to Nuremberg's trade fairs, particularly around the Toy Fair in late January or the Christmas markets research season in November, should book early, since seat availability tightens fast during these niche but high-demand periods.
Seasonally, the January-through-March and October-November windows consistently offer the softest business class pricing on this corridor, as leisure demand dips and airlines discount premium cabins to fill them ahead of summer's surge. Given the complexity of routing through three possible U.S. hubs and two plausible German gateways, fares here fluctuate more than on simpler transatlantic routes — which is exactly why setting up automated fare alerts for New Orleans–Nuremberg business class is the smartest move before you commit to a booking.