Nuremberg's modest airport has no direct widebody service from the United States, which means every seasoned traveler booking business class from Newark to Nuremberg is really booking a connection through Frankfurt or Munich, then hopping a short intra-European flight on Lufthansa. That's the essential fact worth knowing upfront: there is no nonstop option on this city pair, and the routing you choose shapes the entire experience. United flies EWR-Frankfurt nonstop in its Polaris cabin, a lie-flat product with direct aisle access from every seat, while Lufthansa offers the same Newark-Frankfurt sector aboard its A340 or 747-8, with select aircraft now featuring the new Allegris business seat with sliding doors on certain configurations. Delta, through its joint venture with Air France-KLM, typically routes passengers via Amsterdam or Paris rather than Frankfurt, which can add complexity but sometimes yields better award availability.
Having flown this connection more times than I can count, my strong recommendation is Frankfurt over Munich as the transfer point, simply because Lufthansa's FRA hub has far more frequent hops to Nuremberg — sometimes six or seven daily — giving you flexibility if your transatlantic leg runs late. One insider trick: book the Frankfurt-Nuremberg segment as a separate short-haul business fare if award space on the connecting itinerary looks thin; Lufthansa often releases single-leg premium seats on this puddle-jumper independently of the long-haul inventory. Arrive at Newark's Terminal C with extra buffer during winter months, when de-icing delays are common and can cascade into missed connections in Frankfurt.
January through March and October into November consistently offer the softest fares and the best award space on this corridor, largely because Nuremberg's business travel calendar (driven by trade fairs like Spielwarenmesse in late January) creates uneven demand that savvy travelers can exploit in the shoulder gaps. Given how much these fares fluctuate week to week across three carriers and multiple routings, setting up automated fare alerts is the smartest way to catch a premium-cabin deal before it disappears.