Strasbourg's modest little airport, tucked against the Rhine, has never seen a widebody in its life—which means anyone booking business class from Omaha to Strasbourg is signing up for a two-connection itinerary almost by definition, since there is no meaningful single-hub routing that avoids it. The most sensible construction I've found over dozens of bookings on this corridor pairs Delta's domestic-to-transatlantic network through Detroit or JFK with Air France's onward metal into Paris, then a short regional hop or high-speed TGV transfer from Charles de Gaulle down to Strasbourg—CDG's rail link under Terminal 2 makes that final leg painless if you've got the connection time. Lufthansa via Frankfurt or Munich is the other logical play, especially given Lufthansa's newer Allegris business class suites now rolling out on select long-haul aircraft, though availability into Omaha's smaller Delta-heavy schedule can be inconsistent depending on codeshare seat release.
Having flown all three carriers' long-haul cabins repeatedly, I'd steer discerning travelers toward Air France's La Première-adjacent business seats on the 777 or A350 for the transatlantic leg, then treat the Paris-Strasbourg segment as a formality rather than a splurge—don't waste points chasing a "business class" domestic French seat that's often just economy with a blocked middle. My insider tip: book the Omaha–Detroit or Omaha–JFK segment as late as your fare rules allow, since Delta frequently releases additional Delta One award space on the transatlantic leg 30-60 days out, well after the Omaha domestic segment locks in.
Fall and late winter—October, November, January through March—consistently produce the softest fares on this itinerary, as Alsace's tourist season quiets and airlines discount premium cabins to fill seats before the spring wine-route crowds return. Given how thin and variable Omaha-originating business class inventory can be on this three-airline route, setting up automated fare alerts is genuinely the smartest way to catch these seasonal dips before they disappear.