There's no nonstop way to bounce a widebody from the theme park capital of the world to the cobblestones of Gornji Grad, which is precisely why routing strategy matters more on this itinerary than almost any other transatlantic pairing I track. Business class from Orlando to Zagreb always involves at least one connection, and after dozens of bookings on this corridor, I can say definitively: the two smartest hubs are Atlanta via Delta and Frankfurt or Munich via Lufthansa, with a final leg operated by Croatia Airlines (OU) into ZAG. Total air time hovers around 10.5 hours excluding layovers, and Delta's Atlanta gateway is the more comfortable connection for MCO-originating travelers thanks to Delta One's flat-bed suites on the transatlantic segment, some of which now feature the newer Delta One Suite with sliding doors on select 767 and A330 aircraft.
The Lufthansa routing deserves special attention if you're chasing product quality: flying MCO-ATL-FRA or building your own connection to MUC gets you access to Lufthansa's business class cabin on the long-haul segment, and depending on aircraft assignment, you may catch early Allegris configurations on select long-haul aircraft, though these are still rolling out fleet-wide, so don't bank on it. The Croatia Airlines segment from Frankfurt or Munich into Zagreb is short and regional, typically an Airbus A319 or similar narrow-body with a recliner-style business seat — perfectly fine for under two hours, but temper your expectations there. My insider tip: build in a 3+ hour connection in Frankfurt rather than Munich if your itinerary allows, since FRA's Lufthansa business lounges are more extensive and better suited to resetting before the short Zagreb hop, especially on morning arrivals when Croatia Airlines slots are sometimes tight.
Seasonally, this route rewards patience — January, February, March, October, and November consistently produce the softest business class fares, as Croatian tourism demand collapses outside the Adriatic summer season while transatlantic capacity stays intact. Given how fragmented and connection-dependent pricing is on this pairing, I'd strongly recommend setting up automated fare alerts rather than manually checking, since award and revenue business class space on the MCO-ZAG corridor shifts quickly and rarely announces itself in advance.