There's no nonstop way to cover the roughly 6,200 miles between San Diego and Alicante, which means every business class from San Diego to Alicante itinerary routes through a major hub — and after flying this corridor repeatedly, I've settled firmly on London as the superior connection over Madrid. American Airlines partners with British Airways on this route, and the smart play is booking AA metal from SAN to a hub like London Heathrow or Philadelphia, then transferring to British Airways or Iberia for the continental leg down to Alicante. Fact worth noting: American Airlines does not operate any transatlantic widebody service from San Diego itself, so your premium cabin experience truly begins once you're on the connecting long-haul segment, typically a British Airways 777 or A350 fitted with the Club Suite — a fully enclosed suite with a sliding door, direct aisle access, and considerably more privacy than the airline's older Club World cabin.
Having routed through Heathrow's Terminal 5 dozens of times, my insider tip is this: if your connection lands you in T5 with over two hours to spare, request access to the Concorde Room if your fare class qualifies — it's quieter and less crowded than the standard Galleries lounges, and the à la carte dining makes a real difference after a long transatlantic hop. Iberia, meanwhile, flies its A330 and A350 aircraft with lie-flat business seats out of Madrid, and connecting there instead of London can sometimes shave an hour off total journey time if your onward Alicante flight aligns well — just be mindful that Iberia's Madrid connections to secondary Spanish cities like Alicante often use narrower regional configurations, so don't expect lie-flat seating on that final short hop.
Seasonally, April, May, September, and October reward patient travelers with the best combination of fare value and pleasant Costa Blanca weather, avoiding both the summer crowds and winter's thinner schedule. Because pricing on this multi-carrier itinerary fluctuates with hub competition between London and Madrid routings, setting up automated fare tracking for this specific city pair is the most reliable way to catch a favorable window before it closes.