Vilnius remains one of the more elusive prizes for points-hungry travelers on the West Coast, largely because no carrier offers a one-stop routing that doesn't involve real strategy. There is no nonstop option here — anyone booking business class from San Diego to Vilnius should plan on a two-leg journey, typically routing through a major East Coast or European gateway before dropping into VNO on a regional partner aircraft. American, Delta, and United all serve this corridor via their transatlantic joint ventures, which means the savvy move is booking the transatlantic long-haul segment on the carrier with the strongest widebody business product, then accepting a shorter connecting flight into Lithuania on a Star Alliance or SkyTeam regional partner. Delta's connections often route through Amsterdam or Paris via its Air France-KLM joint venture, while United typically funnels through Frankfurt or Munich alongside Lufthansa, and American leans on British Airways or Finnair connections through London or Helsinki — the Helsinki routing, in particular, is worth seeking out given Finnair's proximity and frequency into the Baltics.
Having flown this corridor several times, my strongest recommendation is to prioritize the long-haul segment's seat product over the short connector, since that's where comfort actually matters for a 12.5-hour total journey. United's Polaris seats on 767 or 777 aircraft out of Newark or Washington Dulles are consistently reliable, and Delta's One Suites out of JFK or Boston offer some of the best door-closing privacy in the sky right now. An insider tip few travelers exploit: flying through Helsinki rather than London or Frankfurt often shaves significant connection time and avoids the congestion of Heathrow's Terminal 5 during peak summer months.
Summer remains the sweet spot for this route — May through September brings both favorable weather in Vilnius and the widest schedule flexibility among partner carriers, since Baltic-bound leisure and diaspora traffic peaks then. Fares on these joint-venture routings fluctuate constantly depending on partner award space and cash pricing, so setting continuous fare alerts for this specific SAN-VNO pairing is the only realistic way to catch the periodic pricing dips before they vanish.