Salzburg's compact little airport, tucked beneath the mountains, cannot handle widebody jets from the American Northwest, so anyone booking business class from Seattle to Salzburg is really booking a connection—and the routing you choose matters more than usual. There is no nonstop option; the smart money runs through Frankfurt or Munich on Lufthansa, or through Amsterdam/Zurich patterns via Delta's transatlantic joint venture, before a short intra-European hop covers the final leg into SZG. Delta operates its Airbus A330 or Boeing 767 business cabins with lie-flat Delta One suites out of Seattle to hubs like Amsterdam, while Lufthansa flies its long-haul metal—often equipped with the newer Allegris business suites on select aircraft—into Frankfurt or Munich, both of which offer efficient, well-signed connections to Salzburg on Austrian Airlines or Lufthansa regional jets.
Having flown this corridor more times than I can count, I've learned that Munich is the more forgiving connection when winter weather threatens Salzburg-bound flights, since ground transfers to Austria are a viable backup if the final flight cancels—Salzburg is only about 90 minutes away by train or car from Munich, a fact most itinerary planners never mention. Austrian Airlines' own business class, flown on the short Vienna–Salzburg or Frankfurt–Salzburg legs when routing that way, is modest but efficient, so don't expect a lie-flat experience on the last hop; the real comfort investment happens on the transatlantic segment. If you're connecting through Frankfurt, build in extra buffer time, as immigration and security recheck can eat over an hour during peak summer travel.
Seasonality plays heavily in your favor if you're flexible: January, February, March, October, and November consistently produce softer business class fares on this corridor, as ski season hasn't yet peaked and summer festival crowds have cleared out. Given how many routing permutations exist between Seattle and Salzburg, and how fares shift week to week across Delta, Lufthansa, and Austrian, setting up automated fare alerts is the only realistic way to catch the best business class pricing before it disappears.