Leeds Bradford Airport has no widebody service, which means there's no nonstop option for business class from St. Louis to Leeds — every itinerary routes through a major hub, and the smart money connects once in the US before crossing the Atlantic and then takes a short regional hop or train transfer from a larger UK gateway like Manchester or London. American, Delta, and United all offer viable paths, with American routing through Chicago or Philadelphia onto its Flagship Business cabin (Boeing 777-300ER or 787-9, with the reverse-herringbone seats on the 777), Delta funneling through Detroit or JFK into Delta One suites on the A330-900neo or 767, and United connecting via Chicago O'Hare or Newark into Polaris business on its 767 or 787 fleet. From there, the final leg into Leeds Bradford is typically operated by a regional partner, so I always tell clients to build in a two-hour buffer, since LBA's compact terminal and single runway make it prone to weather-related delays, especially in winter fog.
Having flown all three carriers' transatlantic products repeatedly, my preference leans toward Delta One on the A330-900neo for the door-equipped suite and genuinely restful bedding, though American's Flagship Business shines on meal service out of Philadelphia, where the lounge dining option before departure is underrated. United's Polaris lounges at Chicago O'Hare are worth arriving early for if you're routing that way, particularly the Polaris Lounge's à la carte dining, which beats grabbing food at STL. One tip few travelers know: booking the STL–hub segment as a separate award or cash ticket sometimes opens up better Delta One or Polaris award space on the transatlantic leg than a single connected itinerary would show, since availability is tracked separately by cabin and can vary night to night.
Seasonally, January through March and again in October and November tend to bring the most attainable business class fares and award space on this corridor, as leisure demand to Yorkshire dips outside summer festival season. Because pricing on this route fluctuates with hub routing and seasonal demand, I'd recommend setting up fare alerts to track St. Louis to Leeds business class pricing across all three carriers rather than checking manually, since the best fares tend to appear briefly and without warning.