Montpellier's Méditerranée airport, with its modest regional runway, will never welcome a widebody from the Midwest, which is precisely why the routing puzzle matters more here than on most transatlantic itineraries. There is no nonstop option: business class from St. Louis to Montpellier requires a connection, and after many crossings on this exact corridor, I've settled on two reliable strategies. Delta, in partnership with Air France, routes STL travelers through Detroit or JFK into Paris-Charles de Gaulle, where Air France's domestic and European network offers frequent onward hops to Montpellier via Air France's A220 or regional Embraer jets. Lufthansa's alternative—STL to Frankfurt or Munich, then a short intra-European connection to Montpellier—appeals to those who prefer Lufthansa's long-haul business product, including the newer Allegris cabin now rolling out on select 787 and A350 routes, though not guaranteed on every STL-originating itinerary.
The Frankfurt and Paris hub choice really comes down to personal tolerance for connection style: CDG's Terminal 2E handles Air France's long-haul arrivals with a dedicated business class corridor and access to the excellent Salon Business lounges, while Frankfurt's efficient but sprawling layout rewards travelers who prioritize speed over ambiance. My insider tip, rarely mentioned in generic route guides: when connecting through CDG onward to Montpellier, book the last flight of the day rather than the first, since Air France's regional schedule tends to have far more misconnect padding in the evening bank, reducing the stress of a tight layover after an overnight Atlantic crossing.
Seasonality on this route follows the broader north-America-to-Europe pattern—January, February, March, October, and November consistently offer softer business class fares, as Provence's tourist crush (and associated demand) subsides outside summer. Given the complexity of connections and the fact that award and paid business space on the STL-to-Europe-to-Montpellier chain fluctuates unpredictably across three separate carriers, this is a route where setting up automated fare alerts pays dividends far beyond the effort of manual searching.