Montpellier's regional airport doesn't accommodate widebody service, which means every itinerary from Buffalo funnels through a major European or US hub before the final short hop on a Delta, Air France, or Lufthansa regional partner. There's no nonstop option here, so the real decision for travelers booking business class from Buffalo to Montpellier is which connecting city and which long-haul product to prioritize for the transatlantic leg. My preference, after years of routing through this corner of southern France, is Air France via Paris-CDG: their A350 business class, with direct aisle access and a proper suite-style seat, makes the Buffalo-to-CDG segment (usually connecting through JFK or Detroit on Delta metal under the joint venture) genuinely restful before the quick Air France or low-cost hop down to Montpellier. Delta's own A330-900neo with the Delta One suite is another strong choice if your BUF routing naturally channels through JFK or Boston.
Lufthansa is the wildcard worth considering: routing through Frankfurt or Munich lets you sample their newer Allegris business class on select long-haul aircraft, though availability on this specific configuration remains inconsistent, so it pays to check the actual aircraft type at booking rather than assume. Whichever hub you choose, build in at least a two-hour connection in Paris or Frankfurt during summer, when Schengen passport control queues can eat into tight layovers — Montpellier-bound travelers especially benefit from clearing immigration at their first EU port of entry so the final short flight feels domestic.
An insider trick I've used repeatedly: search Marseille as a backup arrival airport and rent a car for the ninety-minute drive to Montpellier, since Marseille often has better business class award availability and a wider spread of connecting times than the smaller MPL itself. January through March and October into November consistently deliver the softest business class fares on this corridor, as Provence and Languedoc tourism slows and airlines discount premium cabins to fill seats. Given how much these fares fluctuate hub to hub, setting up automated fare alerts is the smartest way to catch a favorable business class fare before it disappears.