Nuremberg's modest airport, tucked into the Bavarian countryside, has never had the connectivity to justify a nonstop from Western New York, which means business class from Buffalo to Nuremberg always runs through a major hub connection—and understanding which one to choose is the whole game. There is no direct routing, full stop; every itinerary funnels through Delta's Atlanta or JFK gateways, American's Philadelphia or Charlotte hubs, or United's Newark and Chicago operations, before crossing the Atlantic to Frankfurt or Munich and finishing on a short regional hop into Nuremberg. In practice, the transatlantic leg is where your business class experience really lives, since that connecting flight into NUE is typically operated on a narrowbody with a basic Europe-style business cabin—so the real prize is booking Delta's A330 or A350 with the reverse-herringbone Delta One suite, American's 777 or 787 with Flagship Suite (or the newer Flagship Suites on retrofitted 777-300ERs), or United's Polaris seats on its 767 or 777 fleet for the long haul.
Having flown this corridor more times than I can count, my strongest advice is to route through Munich rather than Frankfurt when possible—Munich's compact terminal design and efficient passport control make the connection into Nuremberg dramatically less stressful, especially after an overnight transatlantic flight when you're groggy and just want to get to your hotel. If Frankfurt is your only option, build in extra connection time, as the terminal transfers there can be surprisingly long even for premium passengers with lounge access. Seasonally, Nuremberg sees a spike in demand around its famous Christkindlesmarkt in late November and December, and again during trade fair season in spring, so locking in award space or premium fares outside those windows—particularly January through March, or October into early November—yields far better availability and comfort in Delta One, Flagship Suite, or Polaris cabins alike.
One insider trick worth knowing: positioning yourself on a Thursday or Saturday departure from Buffalo often opens up better business class award space on the transatlantic legs, since business travelers cluster on Sunday and Monday outbound flights. Given how much these fares fluctuate with fuel surcharges and seasonal demand, it's worth setting up dedicated fare alerts for this Buffalo–Nuremberg corridor so you can pounce the moment premium cabin pricing dips.