There's no nonstop path linking these two cities, and anyone booking business class from Buffalo to Sarajevo needs to accept that the real strategy lies in the connection, not the origin airport. Buffalo Niagara International is a modest regional field, so your first leg is inevitably a domestic hop or a quick repositioning flight to a major hub before the transatlantic segment even begins. In practice, that means routing through Delta's JFK or Detroit hub for a codeshare into Europe, or connecting via a Lufthansa gateway like Frankfurt or Munich, or funneling through Istanbul on Turkish Airlines — all three carriers serve this city pair in combination with partners, and each delivers a distinct long-haul product worth choosing deliberately.
My preference, having routed this journey more times than I can count, is Lufthansa via Frankfurt or Munich, where the newer Allegris business class suites (on select 787 and A350 rotations) offer sliding doors and genuine privacy — though on this itinerary you may still find yourself on an older long-haul configuration, so it's worth checking the specific aircraft before booking. Turkish Airlines via Istanbul is the sentimental favorite for regional flavor: their business class comes with a full lounge experience at IST that rivals any in Europe, complete with a cinema room and live cooking stations, and the shorter regional hop down to Sarajevo afterward feels almost like a bonus flight. Delta's advantage is domestic convenience out of Buffalo, connecting through JFK or Detroit into a Delta One product before handing off to a European partner for the final descent into Sarajevo's compact, easy-to-navigate airport — arrive with time to spare during summer, when Balkan tourist traffic spikes, but January through March and October into November are reliably the softest months for premium fares.
Insider tip: Sarajevo-bound connections through Istanbul often price lower when booked as a single Turkish Airlines ticket rather than mixing carriers, even though the routing looks similar — a quirk worth testing before you commit. Given how much these fares shift by season and hub, setting up automated fare alerts for this specific routing is the smartest way to catch a premium seat without overpaying.