Montpellier's charm lies precisely in its lack of a major international airport, which means there's no nonstop business class from Chicago to Montpellier — instead, savvy travelers route through Paris, Frankfurt, or London and complete the journey on a short connecting hop into MPL. Of the three, Air France's routing through Charles de Gaulle tends to be the most seamless, since AF operates the highest frequency of connections down to Montpellier and often uses the same terminal (2E) for both long-haul and regional flights, minimizing the transfer scramble. On the transatlantic leg, Air France's 787 or A350 business class cabins offer fully flat seats with direct aisle access, a meaningful upgrade over their older 777 configurations, so if you have flexibility, try to confirm equipment type before booking.
Lufthansa routes through Frankfurt, where the new Allegris business class is gradually rolling out on select 787 and A350 routes — worth chasing if your dates align, since the suite doors and improved seat privacy are a real step up from Lufthansa's legacy product. British Airways, meanwhile, connects via Heathrow's Terminal 5, and their Club Suite — with its sliding door and consistent fleet-wide rollout — remains one of the more reliable European business products, though the Montpellier connection from LHR often means a slightly longer layover than the AF or LH routings. My insider tip: book the outbound connection with at least 90 minutes of buffer in Paris or Frankfurt, since regional gates are frequently a long walk or bus ride from the international arrivals concourse, and MPL-bound flights sometimes depart from remote stands.
January through March and October into November remain the sweet spot for this itinerary, both for fare softness and for avoiding the crowded summer Provence rush. Given how much these fares fluctuate week to week depending on connection city and cabin availability, it's worth setting up automated fare alerts so you can pounce the moment premium inventory opens up on your preferred routing.