Few itineraries expose the vast geography of transpacific-transatlantic travel quite like the journey from Hawaii to Alsace, and there's no way to sugarcoat it: business class from Honolulu to Strasbourg requires at least two connections, since no airline routes passengers through a single hub for this pairing. The most reliable structure I've found after flying variations of this route repeatedly is Delta or Air France via Los Angeles or Seattle, then onward through Paris Charles de Gaulle, with a final short hop to Strasbourg's compact regional airport. Lufthansa offers an alternative through Frankfurt, useful if you're chasing a specific fare class or want to try their newer Allegris business seats, currently rolling out on select long-haul aircraft. The unavoidable fact worth noting for planning purposes: total transit time including connections typically runs 20-24 hours door to door, so building in a Paris or Frankfurt layover of several hours—rather than a tight connection—preserves both sanity and lounge access.
Air France's La Première and Business cabins on the Los Angeles-Paris sector are where this trip earns its comfort, particularly on the A350 with its intimate cabin layout and genuinely restful seat design; Delta's One Suites on the Honolulu-mainland or transpacific legs offer sliding doors and solid ergonomics for the long haul across the Pacific. My insider tip: fly the Honolulu-to-mainland segment overnight to arrive in Los Angeles or Seattle with enough buffer for a proper meal before the transatlantic leg, rather than rushing a tight same-day connection—jet lag compounds brutally on this east-then-further-east routing. Strasbourg's airport is small and efficient, but confirm your final connection isn't the last flight of the day, as weather delays from Paris can strand you overnight.
January through March and October through November consistently offer the softest fares on this itinerary, as European leisure demand dips and Air France/Delta adjust premium cabin pricing accordingly. Given the multi-carrier complexity and fare volatility here, setting up automated price tracking for this specific routing will save far more than manual searching ever could.