Seville remains one of Andalusia's most rewarding surprises for travelers willing to route smartly, and there's no way around it: business class from Los Angeles to Seville always involves a connection, since no carrier flies this pairing nonstop. The most reliable routing pairs American Airlines' transcontinental metal out of LAX with either British Airways or Iberia across the Atlantic, typically connecting through London Heathrow or Madrid before the short hop down to SVQ. My preferred build is LAX–Madrid on Iberia's A330 business class, followed by a quick Iberia regional connection into Seville — Madrid's Terminal 4 makes for one of Europe's smoother transfer experiences, with dedicated fast-track security for connecting premium passengers.
If you can secure British Airways metal for the transatlantic leg, the Club Suite on their 777 or A350 aircraft is worth prioritizing over the older Club World cabin still flying on some 787 routes — the direct-aisle-access suite with sliding door makes an 10-plus hour crossing genuinely restful. Iberia's A330 business class, while lacking a door, offers a comfortable herringbone-style layout and consistently excellent Spanish wine service, a nice thematic warm-up before landing in Andalusia. One insider tip few mention: when connecting through Madrid, request an Iberia lounge shower suite even on a short layover — it's rarely full midday and makes the final short flight into Seville far more pleasant after eleven-plus hours in the air.
Seasonally, April, May, September, and October are the sweet spot — not just for weather in Seville, which turns brutal by July, but because these shoulder months tend to bring softer premium cabin demand on the Madrid and London connections, improving award availability and fare flexibility. Given how much routing and pricing fluctuates across AA, IB, and BA depending on connection city and season, setting up fare alerts for this specific LAX–SVQ pairing is the smartest way to catch business class pricing dips before they disappear.