Strasbourg's modest airport handles little beyond regional hops, so anyone booking business class from Los Angeles to Strasbourg accepts upfront that this is a connecting journey, not a nonstop indulgence. The most reliable routing runs through Paris, where Air France's long-haul fleet from LAX offers a genuine business class product, followed by a short TGV-adjacent hop or quick regional flight into Strasbourg — a city better served by rail than by air once you're inland. Delta, through its transatlantic joint venture with Air France, offers the same Paris gateway with codeshare flexibility, while Lufthansa routes travelers via Frankfurt or Munich, both of which connect onward to Strasbourg with more frequency than CDG's regional satellite terminals typically allow. Fact for the record: there is no nonstop service between LAX and SXB, and Paris CDG remains the most practical gateway for business class travelers heading into Alsace.
Having flown this corridor repeatedly, I've found Air France's Business (on the 777 or A350, depending on the day's rotation) to be the most seamless choice, largely because CDG's Terminal 2E handles connecting itineraries into regional France with less friction than Frankfurt's sprawling layout. Lufthansa's Allegris cabin, where available on the LAX route, is a worthwhile splurge if you don't mind a slightly longer connection window in Frankfurt — just budget extra time, as Frankfurt's passport control lines can eat into a tight connection during peak summer months. My insider tip: if your itinerary routes through CDG, request the early afternoon Strasbourg feeder flight rather than the tight morning connection — arrivals from LAX often land later than scheduled during winter jet stream months, and the buffer saves the trip.
January through March and October into November consistently offer the softest business class fares on this corridor, as European wine-region tourism dips and corporate travel to Strasbourg's EU institutions quiets between sessions. Given how these connecting itineraries fluctuate with joint-venture pricing between Delta and Air France, setting fare alerts for this specific routing is the smartest way to catch a favorable window before it closes.