Rhodes has never had a direct connection to Southern California, and after a dozen bookings on this itinerary, I've come to accept that the routing is the real product here. There is no nonstop option for business class from San Diego to Rhodes, so the itinerary always hinges on which European gateway you choose to bridge the Atlantic and Aegean. My preferred build is San Diego to Frankfurt or Munich on Lufthansa, connecting onward to Rhodes via Athens on Aegean Airlines, whose short-haul business class product is understated but efficient, with blocked middle seats and proper Greek catering that beats most transatlantic economy meals. Lufthansa's long-haul cabins vary by aircraft, and if you can secure a rotation featuring the newer Allegris business suite with a closing door, it transforms the 10-hour transatlantic leg; older 747-8 or A340 configurations are serviceable but dated by comparison, so I always check equipment before booking.
British Airways offers the other logical path, routing through London Heathrow with its Club Suite on the 787 or A350, a genuine step up thanks to direct aisle access and a proper flat bed—Terminal 5's dedicated Concorde Room lounge makes the layover feel like part of the trip rather than a delay. From Heathrow, you'll typically connect onto a BA or partner flight into Athens before a short Aegean hop to Rhodes, since BA doesn't fly directly into RHO. Whichever hub you choose, build in at least two hours in Athens for the Rhodes connection, as Aegean's schedule bank there is tight but reliable in shoulder season.
Rhodes itself is seasonal in the extreme—flights thin out drastically from November through March, so April, May, September, and October aren't just pleasant weather windows, they're also when award and premium cash space loosens up meaningfully. My insider tip: search Munich as your transatlantic gateway rather than Frankfurt, since Lufthansa's Rhodes-adjacent Greek connections often price lower through MUC despite similar routing. Given how much these Athens-linked fares fluctuate, setting up automated fare tracking for this specific city pair is the smartest way to catch the shoulder-season sweet spots before they vanish.